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Paroxetine
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IMPORTANT WARNING:
Studies have shown that children and teenagers who
take antidepressants ('mood elevators') such as
paroxetine may be more likely to think about harming or
killing themselves or to plan or try to do so than
children who do not take antidepressants. Children
younger than 18 years of age should not normally take
paroxetine.If your child's doctor has prescribed
paroxetine for your child, you should watch his or her
behavior very carefully, especially at the beginning of
treatment and any time his or her dose is increased or
decreased. Your child may develop serious symptoms very
suddenly, so it is important to pay attention to his or
her behavior every day. Call your child's doctor right
away if he or she experiences any of these symptoms: new
or worsening depression; thinking about harming or
killing him- or herself or planning or trying to do so;
extreme worry; agitation; panic attacks; difficulty
falling or staying asleep; irritability; aggressive
behavior; acting without thinking; severe restlessness;
frenzied, abnormal excitement; or any other sudden or
unusual changes in behavior.Your child's doctor will
want to see your child often while he or she is taking
paroxetine, especially at the beginning of his or her
treatment.Your child's doctor may also want to speak
with you or your child by telephone from time to time.
Be sure that your child keeps all appointments for
office visits or telephone conversations with his or her
doctor.Your child's doctor or pharmacist will give you
the manufacturer's patient information sheet (Medication
Guide) when your child begins treatment with paroxetine.
Read the information carefully and ask your child's
doctor or pharmacist if you have any questions.
Medication Information
Paroxetine tablets,
suspension (liquid) and extended-release (long-acting)
tablets are used to treat depression, panic disorder
(sudden, unexpected attacks of extreme fear and worry
about these attacks), and social anxiety disorder
(extreme fear of interacting with others or performing
in front of others that interferes with normal life).
Paroxetine tablets and oral solution are also used to
treat obsessive compulsive disorder (bothersome thoughts
that won't go away and the need to perform certain
actions over and over), generalized anxiety disorder
(excessive worrying that is difficult to control), and
posttraumatic stress disorder (disturbing psychological
symptoms that develop after a frightening experience).
Paroxetine extended-release tablets are also used to
treat premenstrual dysphoric disorder (PMDD, physical
and psychological symptoms that occur before the onset
of the menstrual period each month). Paroxetine is in a
class of medications called selective serotonin reuptake
inhibitors (SSRIs). It works by increasing the amount of
serotonin, a natural substance in the brain that helps
maintain mental balance.
How should Paroxetine be used?
Paroxetine comes
as a tablet, a suspension (liquid), and a
controlled-release (long-acting) tablet to take by
mouth. It is usually taken once daily in the morning or
evening, with or without food. You may want to take
paroxetine with food to stop it from upsetting your
stomach. To help you remember to take paroxetine, take
it around the same time every day. Follow the directions
on your prescription label carefully, and ask your
doctor or pharmacist to explain any part you do not
understand. Take paroxetine exactly as directed. Do not
take more or less of it or take it more often than
prescribed by your doctor.
Shake the liquid well before each use to mix the
medication evenly.
Swallow the extended-release tablets whole; do not
split, chew, or crush them.
Your doctor may start you on a low dose of paroxetine
and gradually increase your dose, not more than once a
week.
Paroxetine controls your condition but does not cure
it. It may take several weeks or longer before you feel
the full benefit of paroxetine. Continue to take
paroxetine even if you feel well. Do not stop taking
paroxetine without talking to your doctor. Your doctor
will probably decrease your dose gradually. If you
suddenly stop taking paroxetine, you may experience
withdrawal symptoms such as depression; mood changes;
frenzied or abnormally excited mood; irritability;
anxiety; confusion; dizziness; headache; tiredness;
numbness or tingling in the arms, legs, hands, or feet;
unusual dreams; difficulty falling asleep or staying
asleep; upset stomach; or sweating. Tell your doctor if
you experience any of these symptoms when your dose of
paroxetine is decreased.
Other uses for Paroxetine
Paroxetine is also
sometimes used to treat chronic headaches, tingling in
the hands and feet caused by diabetes, and certain male
sexual problems. Paroxetine is also used with other
medications to treat bipolar disorder (mood that changes
from depressed to abnormally excited ). Talk to your
doctor about the possible risks of using Paroxetine for
your condition.
Paroxetine may be prescribed for other uses; ask your
doctor or pharmacist for more information.
What special precautions should I follow?
Before taking paroxetine,
- tell your doctor and pharmacist if you are
allergic to paroxetine or any other medications. do
not take paroxetine if you are taking monoamine
oxidase (MAO) inhibitors, including isocarboxazid
(Marplan), phenelzine (Nardil), selegiline (Eldepryl),
and tranylcypromine (Parnate), or have stopped taking
them within the past two weeks. If you stop taking
paroxetine, you should wait at least 2 weeks before
you start to take an MAO inhibitor. Do not take
paroxetine if you are taking thioridazine (Mellaril).
- tell your doctor and pharmacist what other
prescription and nonprescription medications, and
vitamins you are taking. Be sure to mention any of the
following: anticoagulants ('blood thinners') such as
warfarin (Coumadin); antidepressants (mood elevators)
such as amitriptyline (Elavil), amoxapine (Asendin),
clomipramine (Anafranil), desipramine (Norpramin),
doxepin (Adapin, Sinequan), imipramine (Tofranil),
nortriptyline (Aventyl, Pamelor), protriptyline
(Vivactil), and trimipramine (Surmontil);
antihistamines; aspirin and other nonsteroidal
anti-inflammatory medications (NSAIDs) such as
ibuprofen (Advil, Motrin), and naproxen (Aleve,
Naprosyn); atazanavir (Reyataz); bromocriptine
(Parlodel); bupropion (Wellbutrin); buspirone
(Buspar); celecoxib (Celebrex); chlorpromazine
(Thorazine); cimetidine (Tagamet); clopidogrel
(Plavix); codeine (found in many cough and pain
medications); dexamethasone (Decadron);
dextromethorphan (found in many cough medications);
diazepam (Valium); dicloxacillin (Dynapen); digoxin
(Lanoxin); dipyridamole (Persantine); diuretics
('water pills'); haloperidol (Haldol); isoniazid (INH,
Nydrazid); lithium (Eskalith, Lithobid); medications
for irregular heartbeat such as amiodarone (Cordarone,
Pacerone), encainide (Enkaid), flecainide (Tambocor),
mexiletine (Mexitil), moricizine (Ethmozine):
propafenone (Rythmol), and quinidine (Quinidex);
medications for mental illness and nausea; medications
for seizures such as phenobarbital (Luminal, Solfoton)
and phenytoin (Dilantin); meperidine (Demerol);
methadone (Dolophine); metoclopromide (Reglan);
metoprolol (Lopressor, Toprol XL); odansetron
(Zofran); other selective serotonin reuptake
inhibitors such as citalopram (Celexa), fluoxetine
(Prozac, Sarafem); fluvoxamine (Luvox); and sertraline
(Zoloft); pimozide (Orap); procyclidine (Kemadrin);
propoxyphene (Darvon); propranolol (Inderal);
ranitidine (Zantac); rifampin (Rifadin, Rimactane);
risperidone (Risperdal); ritonavir (Norvir);
sumatriptan (Imitrex); tamoxifen (Nolvadex);
terbinafine (Lamisil); theopylline (Theobid,
Theo-Dur); ticlopidine (Ticlid); timolol (Blocadren);
tramadol (Ultram); trazodone (Desyrel); and
venlafaxine (Effexor). Your doctor may need to change
the doses of your medications or monitor you carefully
for side effects.
- tell your doctor what herbal products and
nutritional supplements you are taking, especially St.
John's wort and tryptophan.
- tell your doctor if you or anyone in your family
has or has ever had depression, bipolar disorder (mood
that changes from depressed to abnormally excited), or
mania (frenzied, abnormally excited mood), or if you
or anyone in your family has thought about or
attempted suicide. Also tell your doctor if you use or
have ever used street drugs or have overused
prescription medications, if you have recently had a
heart attack, and if you have or have ever had
glaucoma (an eye disease); seizures; bleeding from
your stomach or esphagus (tube that connects the mouth
and stomach) or liver, kidney, or heart disease.
- tell your doctor if you are pregnant, plan to
become pregnant, or are breast-feeding. If you become
pregnant while taking paroxetine, call your doctor.
you should know that paroxetine may make you drowsy
and affect your judgment and thinking. Do not drive a
car or operate machinery until you know how Paroxetine
affects you.
- ask your doctor about the safe use of alcoholic
beverages while you are taking paroxetine. you should
know that your mental health may change in unexpected
ways, especially at the beginning of your treatment
and any time that your dose is increased or decreased.
These changes may occur at any time if you have
depression or another mental illness, whether or not
you are taking paroxetine or any other medication.
You, your family, or caregiver should call your doctor
right away if you experience any of the following
symptoms: new or worsening depression; thinking about
harming or killing yourself, or planning or trying to
do so; extreme worry; agitation; panic attacks;
difficulty falling asleep or staying asleep;
aggressive behavior; irritability; acting without
thinking; severe restlessness; and frenzied abnormal
excitement. Be sure that your family or caregiver
knows which symptoms may be serious so they can call
the doctor when you are unable to seek treatment on
your own.
What special dietary instructions should I follow?
Unless your doctor tells you otherwise, continue
your normal diet.
What should I do if I forget a dose?
Take the
missed dose as soon as you remember it. However, if it
is almost time for the next dose, skip the missed dose
and continue your regular dosing schedule. Do not take a
double dose to make up for a missed one.
What side effects can Paroxetine cause?
Paroxetine may cause side effects. Tell your doctor
if any of these symptoms are severe or do not go away:
- headache
- dizziness
- weakness
- difficulty concentrating
- nervousness
- forgetfulness
- confusion
- sleepiness or feeling "drugged"
- difficulty falling asleep or staying asleep
- upset stomach
- vomiting
- diarrhea
- constipation
- gas
- stomach pain
- heartburn
- changes in ability to taste food
- decreased appetite
- weight loss or gain
- changes in sex drive or ability
- dry mouth
- sweating
- yawning
- sensitivity to light
- runny nose
- cough
- lump or tightness in throat
- pain in the back, muscles, joints, or anywhere in
the body
- muscle weakness or tightness
- flushing
- problems with teeth
- unusual dreams
- painful or irregular menstruation
Some side effects can be serious. The following
symptoms are uncommon, but if you experience any of them
or those listed in the IMPORTANT WARNING section, call
your doctor immediately:
- blurred vision
- rapid, pounding, or irregular heartbeat
- chest pain
- seizure
- abnormal bleeding or bruising
- sore throat, fever, chills, and other signs of
infection
- shaking hands that you cannot control
- sudden muscle twitching or jerking that you cannot
control
- numbness or tingling in your hands, feet, arms, or
legs
- difficult, frequent, or painful urination
- swelling, itching, burning, or infection in the
vagina
- painful erection that lasts for hours sudden upset
stomach, vomiting, weakness, cramping, bloating,
swelling, tightness in hands and feet, dizziness,
headache and/or confusion
- hives
- skin rash
- itching
- swelling of the face, throat, tongue, lips, eyes,
hands, feet, ankles, or lower legs
- hoarseness
- difficulty breathing or swallowing
- black and tarry stools
- red blood in stools
- bloody vomit
- vomiting material that looks like coffee grounds
Paroxetine may cause other side effects. Call your
doctor if you have any unusual problems while taking
Paroxetine.
What storage conditions are needed for
Paroxetine?
Keep Paroxetine in the container it came
in, tightly closed, and out of reach of children. Store
it at room temperature and away from excess heat and
moisture (not in the bathroom). Throw away any
medication that is outdated or no longer needed. Talk to
your pharmacist about the proper disposal of your
medication.
In case of emergency/overdose
In case of
overdose, call your local poison control center at
1-800-222-1222. If the victim has collapsed or is not
breathing, call local emergency services at 911.
Symptoms of overdose may include:
- drowsiness
- coma
- upset stomach
- shaking hands that you cannot control
- fast, pounding, irregular, or slow heartbeat
- confusion
- vomiting
- dizziness
- seizures
- fainting
- blurred vision
- extreme tiredness
- unusual bruising or bleeding
- lack of energy
- loss of appetite
- pain in the upper right part of the stomach
- flu like symptoms
- yellowing of the skin and eyes
- aggressive behavior
- muscle pain, stiffness or weakness
- sudden muscle twitching or jerking that you cannot
control
- dark red or brown urine
- difficulty urinating
- diarrhea
- frenzied, abnormally excited mood
- sweating
- fever
- difficulty walking
What other information should I know?
Keep all
appointments with your doctor.
Do not let anyone else take your medication. Ask your
pharmacist any questions you have about refilling your
prescription. |
